She married her high school sweetheart, the poet Stan Rice, when she was twenty, and she held a variety of jobs, including cook, waitress, and insurance claims adjuster. She gave birth to a daughter, and wrote sporadically during these years; but when her daughter died of leukemia at the age of five, Rice channeled her grief into her first vampire novel,
Interview with the Vampire, which she completed in only six weeks. The book was deemed a success, but Rice's depression was severe enough to cause her and her husband to drink heavily. Though she continued to write, and even completed
The Feast of All Saints, their productivity was limited until their son was born. Finally overcoming her alcohol problem, Rice continued to write more vampire novels, as well as several volumes of erotica, and a new series involving a sect of witches in New Orleans.
The success of Interview with a Vampire spurred more vampire books based on secondary characters in her original book; these include The Vampire Lestat,Queen of the Damned,Tale of the Body Thief,Memnoch the Devil, and The Vampire Armand, and Blood and Gold (2001), which follows the life of the vampire Marius from Imperial Rome to Constantinople to Venice during the Renaissance the present day.
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