William Burton may refer to:
- William Burton (antiquary) (1575-1645), author of The Description of Leicestershire, 1622
- William Burton (translator) (16th century), English translator of Achilles Tatius
- William Henry Burton (1739-1818), a UK MP for the Irish constituency of County Carlow 1801-1802
- William George Burton (1774-1825), printer and author
- William Burton (governor) (1789-1866), governor of Delaware
- W. K. Burton (William Kinnimond Burton, 1856–99), British engineer, photographer and photography writer
- William Westbrooke Burton (1794-1888), judge in New South Wales etc.
- William Evans Burton (1804-1860), actor and playwright
- William Francis Burton, (1907-1995), marine and landscape artist
- William Burton (1888-1944), mayor of Hamilton, Ontario
- William Merriam Burton, American chemist
- William Allen Burton (1949-present), semi-professional billiards player and billiard memorabilia collector
- William Burton (chemist), an English chemist contracted to Josiah Wedgwood and Sons.
- William Harry Burton, an Canadian Student living in Austria.
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