Tumor suppressor genes regulate mitosis and cell division. When their function is impaired, the result is a high rate of uncontrolled cell growth or cancer. Damage to tumor suppressor genes contributes to a large number of different types of tumors....

Cell proliferation is a highly regulated process in which two classes of genes play crucial roles, proto-oncogenes and tumor suppressor genes. Proto-oncogenes induce cell proliferation, and tumor suppressor genes control the levels of proto-oncogenic...

A tumor suppressor gene is a gene that reduces the probability that a cell in a multicellular organism will turn into a tumor cell. A mutation or deletion of such a gene will increase the probability of the formation of a...

Researchers disagree about the carcinogenicity of the multiple tumor suppressor 1 (MTS1) gene. One research team found the gene in almost half of tumor cells raised in the laboratory, but other researchers have found MTS1 much less often in tumor cells taken from patients....

Researchers Limin Li and Stanley N. Cohen and their colleagues have used a new gene discovery strategy to locate tumor suppressor gene tsg101 on chromosome 11. The strategy allows researchers to knock out the activity of both copies of a randomly selected gene. ...

Biologist Marguerite Vogt succeeded by focusing singularly on her goal -- advancing science.She studied how organisms develop, then applied insights to make important strides in polio and cancer research.Several newer drugs and targeted therapies wouldn't exist now, scientists say, had Vogt and a fellow researcher's...