The Witches of Karres combines an unconventional young man's search for his niche in life with an elaborate narrative of political and commercial intrigue on a grand scale. In this book, set in the distant future, humanity has colonized much of the galaxy, and has diversified into a variety of types, some with very special powers. It is a chance encounter with three young citizens of the planet Karres, whose metaphysical powers have earned them and their community the title of witches, that propel the young man into strange adventures.
Among its most timely themes, common to Schmitz's work, is the idea that each individual needs to be capable of taking care of himself. Female and male characters, human or otherwise, are equally represented in every profession, from shipwright to secret agent.