Orthogonal Coordinate System
A coordinate system is a way of naming the points of n-dimensional space with n-tuples of real numbers so that no two points have the same name. For example, a line can be...
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Mixed mode chromatography combines aspects of ion exchange chromatography and conventional reversed-phase (RP) chromatography. The combination of both hydrophobic and ion-exchange properties allows...
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At the American Association of Pharmaceutical Scientists (AAPS) Annual Meeting in San Antonio last fall, several speakers shed light on one of the challenges of formulating injectable proteins: add...
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Hyphenation of gas chromatography (GC) with mass spectrometry (MS) allows identification and quantification of a wide range of trace amounts of GC-amenable compounds in complex matrices. Until now,...
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A tremendous amount of analytical testing is required to support a biopharmaceutical product from discovery, development, and clinical trials, through manufacturing and marketing. Numero...
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ABSTRACT
This article discusses how on-line high-performance liquid chromatography (HPLC) can measure product purity in the column eluent stream in near–real time. These da...
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ABSTRACT
Affinity purification schemes for antibody production have certain limitations keeping up with cell culture expression levels as they reach and exceed 10 g/L. New downst...
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Basically, the response of a chromatographic detector is typically evaluated from the peak area of eluting species. This area (A) can be expressed as the integral of responses over the elution time...
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Orthogonal Coordinate System
A New Weak Anion-Exchange/Reversed-Phase Mixed-Mode Stationary Phase for Simultaneous Separation of Basic, Acidic and Neutral Pharmaceuticals
