Research into the structure and function of oncogenes has been a major endeavor for many years. The first chromosome rearrangement (Ph') involving a proto-oncogene to be directly associated with cancer induction was identified in 1960. Since then, over...

Proto-oncogenes are functional structural genes present in the human genome that have sequences very similar to oncogenes seen in viruses. Under normal conditions, the proto-oncogenes perform vital functions in the cell. They have been shown to be...

Oncogenes are segments of genetic material (DNA) that are able to induce cancer in animals. They were first discovered in retroviruses (viruses containing the enzyme, reverse transcriptase, and RNA rather than DNA) that were found to cause cancer in...

Oncogenes are a special type of gene that is capable of transforming host cells and triggering carcinogenesis. The name is derived from the Greek onkos, meaning bulk, or mass, because of the ability to cause tumor growth. Oncogenes were first...

An oncogene is a modified gene, or a set of nucleotides that codes for a protein and is believed to cause cancer. Genetic mutations resulting in the activation of oncogenes increase the chance that a normal cell will develop into a tumor cell. Since the...

PRESENTATIONS Imaging, in combination with physical examination and pathologic evaluation, is a key clement of cancer diagnosis and staging. To date, cancer imaging largely focuses on determining the precise localization of the primary tumor and sites of metastatic disease. Elements of a diagnostic...

| HOT PAPERS | DJ-1 spurs a rethink on neurodegenerative mechanisms The discovery of several genes linked to Parkinson disease (PD) in recent years has spawned extensive research efforts to elucidate the underlying mechanism of this prevalent neurological disorder. This issue's hot Paper...

Biologist Marguerite Vogt succeeded by focusing singularly on her goal -- advancing science.She studied how organisms develop, then applied insights to make important strides in polio and cancer research.Several newer drugs and targeted therapies wouldn't exist now, scientists say, had Vogt and a fellow researcher's...