DNA and RNA are polymers made by linking together smaller units called nucleotides. Nucleases are enzymes that break the chemical bonds, called phosphodiester bonds, that hold the nucleotides of DNA or RNA polymers together. Enzymes that cleave the...

Nucleases are ubiquitous phosphodiesterase enzymes that cleave phosphodiester bonds within nucleic acid molecules. They are indispensable for the both cellular and viral development. Nucleases that are specific for DNA are called deoxyribonucleases...

An enzyme that can degrade a DNA molecule by breaking its phosphodiester...

A nuclease is an enzyme capable of cleaving the phosphodiester bonds between the nucleotide subunits of nucleic acids. Older papers may use terms such as "polynucleotidase" or...

Research involving RNA and DNA has become increasingly important in the molecular biology field. But these molecules can be tricky to work with. RNase and DNase, ubiquitous enzymes in the typical lab environment that degrade RNA and DNA, sharply reduce yields and product...

ABSTRACT This report describes high-frequency germline gene targeting at two genomic loci in Drosophila melanogaster, y and ry. In the best case, nearly all induced parents produced mutant progeny; 25% of their offspring were new mutants and most of these were targeted gene...