Naloxone is an OPIOID ANTOGONIST (i.e., a blocker of morphine-like agents) commonly used to reverse the actions of drugs such as morphine. In the early 1990s, it was the treatment of choice for reversing the life-threatening effects of opioid overdose....

A drug that is a selective blocker of OPIATE RECEPTORS. Naloxone is a well-known opiate ANTAGONIST as is the structurally similar compound NALTREXONE. Naloxone binds to opiate receptors and blocks them until the drug is metabolized, preventing opiate...

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ABSTRACT Introduction. Naloxone is a medication that is frequently administered in the field by paramedics for suspected opioid overdoses. Most prehospital protocols, however, require this medication to be given to patients intravenously (IV) or intramuscularly (IM). Unfortunately, intravenous line placement may be problematic...

To the Editor: Multiple agents are known to cause anaphylactic reactions after surgical or interventional procedures. Opioids are known to cause histamine release and anaphylactic reactions. The mechanisms of these reactions could be either IgE-dependent or IgE independent. (1,2) We describe a case...

In the wake of more than 400 deaths nationwide from heroin laced with the painkiller fentanyl, some needle exchange programs are giving addicts prescriptions for a drug to keep on hand to halt an overdose. The antidote _...

Massachusetts officials next month will begin distributing kits to heroin addicts that include medication to treat overdoses.Advocates say the kits will help treat overdoses quickly, safely and without fear of addiction, and will be beneficial in a state where more people die from heroin than...