The multiple endocrine neoplasia (MEN) syndromes are three related disorders affecting the thyroid and other hormone producing (endocrine) glands of the body. The three forms of MEN are MEN1 (Wermer's syndrome), MEN2A (Sipple syndrome), and MEN2B...

The term multiple endocrine neoplasia (MEN) encompasses several distinct syndromes featuring tumors of endocrine glands, each with its own characteristic pattern. In some cases, the tumors are malignant; in others, they are benign. The older names...

Background: Multiple endocrine neoplasia type 2 (MEN2) is a cancer syndrome with well-characterized causative mutations. Missense mutations in ~15 codons of the RET gene have been linked to disease phenotypes in the vast majority of cases. These missense mutations range from very simple single...

ABSTRACT Dominant mutations in the Ret receptor tyrosine kinase lead to the familial cancer syndrome multiple endocrine neoplasia type 2 (MEN2). Mammalian tissue culture studies suggest that Ret^sup MEN2^ mutations significantly alter Ret-signaling properties, but the precise mechanisms by which Ret^sup MEN2^ promotes...