Main as a surname may refer to
- Anne Main, British politician
- Grant Main, Canadian rower
- John Main, British Benedictine monk
- Marjorie Main, American actress
- Michel Main, French traditionalist Catholic bishop
- Robert Main, British astronomer
- Terence Main (born 1954), an American modernist sculptor
- Sam Main, outspoken homophobe
See also
- Chas. T. Main, company
- Main (disambiguation)
- Maine
- Mayne
