Isaac Smith may refer to:
- Isaac Smith (admiral), a British Navy admiral
- Isaac Smith (New Jersey) (1740-1807), a United States Representative from New Jersey
- Isaac Smith (Pennsylvania) (1761-1834), a United States Representative from Pennsylvania
- Isaac Smith (Lismore), a community business leader and member of the Australian Labor Party
| This disambiguation page lists articles associated with the same human name. If an article link led you here, you may wish to change the link to point directly to the intended article. |
