| Integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
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| PDB rendering based on 1txv. | ||||||||||||||
| Available structures: 1txv, 1ty3, 1ty5, 1ty6, 1ty7, 1tye | ||||||||||||||
| Identifiers | ||||||||||||||
| Symbol(s) | ITGA2B; GTA; CD41; CD41B; GP2B; GPIIb; HPA3 | |||||||||||||
| External IDs | OMIM: 607759 MGI: 96601 Homologene: 37304 | |||||||||||||
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| RNA expression pattern | ||||||||||||||
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| Orthologs | ||||||||||||||
| Human | Mouse | |||||||||||||
| Entrez | 3674 | 16399 | ||||||||||||
| Ensembl | ENSG00000005961 | ENSMUSG00000034664 | ||||||||||||
| Uniprot | P08514 | Q3U3R7 | ||||||||||||
| Refseq | NM_000419 (mRNA) NP_000410 (protein) | NM_010575 (mRNA) NP_034705 (protein) | ||||||||||||
| Location | Chr 17: 39.81 - 39.82 Mb | Chr 11: 102.27 - 102.29 Mb | ||||||||||||
| Pubmed search | [1] | [2] | ||||||||||||
Integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41), also known as ITGA2B, is a human gene.
ITGA2B encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibronectin receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling.[1]
References
Further reading
- Bray PF (1995). "Inherited diseases of platelet glycoproteins: considerations for rapid molecular characterization.". Thromb. Haemost. 72 (4): 492-502. PMID 7878622.
- Naik UP, Parise LV (1997). "Structure and function of platelet alpha IIb beta 3.". Curr. Opin. Hematol. 4 (5): 317-22. PMID 9288464.
- Porter JC, Hogg N (1999). "Integrins take partners: cross-talk between integrins and other membrane receptors.". Trends Cell Biol. 8 (10): 390-6. PMID 9789327.
- Lincoff AM (1998). "Trials of platelet glycoprotein IIb/IIIa receptor antagonists during percutaneous coronary revascularization.". Am. J. Cardiol. 82 (8B): 36P-42P. PMID 9809890.
- Bennett JS (2001). "Platelet-fibrinogen interactions.". Ann. N. Y. Acad. Sci. 936: 340-54. PMID 11460491.
- Plow EF, Cierniewski CS, Xiao Z, et al. (2002). "AlphaIIbbeta3 and its antagonism at the new millennium.". Thromb. Haemost. 86 (1): 34-40. PMID 11487023.
- Quinn MJ, Byzova TV, Qin J, et al. (2004). "Integrin alphaIIbbeta3 and its antagonism.". Arterioscler. Thromb. Vasc. Biol. 23 (6): 945-52. doi:10.1161/01.ATV.0000066686.46338.F1. PMID 12637342.
- Fullard JF (2004). "The role of the platelet glycoprotein IIb/IIIa in thrombosis and haemostasis.". Curr. Pharm. Des. 10 (14): 1567-76. PMID 15134555.
- Watson SP, Auger JM, McCarty OJ, Pearce AC (2005). "GPVI and integrin alphaIIb beta3 signaling in platelets.". J. Thromb. Haemost. 3 (8): 1752-62. doi:10.1111/j.1538-7836.2005.01429.x. PMID 16102042.
- Bennett JS (2006). "Structure and function of the platelet integrin alphaIIbbeta3.". J. Clin. Invest. 115 (12): 3363-9. doi:10.1172/JCI26989. PMID 16322781.
- Ma YQ, Qin J, Plow EF (2007). "Platelet integrin alpha(IIb)beta(3): activation mechanisms.". J. Thromb. Haemost. 5 (7): 1345-52. doi:10.1111/j.1538-7836.2007.02537.x. PMID 17635696.
