Fluorescent in situ hybridization (FISH) is a technique in which single-stranded nucleic acids (usually DNA, but RNA may also be used) are permitted to interact so that complexes, or hybrids, are formed by molecules with sufficiently similar,...

Probes are often derived from fragments of DNA that were isolated, purified, and amplified for use in the Human Genome Project. The size of the human genome is so large, compared to the length that could be sequenced directly, that it was necessary to...

In situ hybridization is a powerful tool for localizing DNA sequences in plant and animal chromosomes. Radiolabeled probes were used in early studies, but the introduction of fluorescent labels has made the method quicker, safer, and more informative. The fluorescence ISH (FISH) technique is...

Sir, We would like to share our experience with acute promyelocytic leukemia (APML) molecular cytogenetic studies. Recent debate regarding interpretation of FISH (Fluorescence in situ hybridization) with BCR/ABL (ES) probe for detection of der(9q) deletion in t (9;22)(q34;q11.2) published in the journal Cancer...

High-frequency sound waves can sketch images of a fetus in the womb. Similar ultrasound technology can also blast away at tumors.That high-intensity focused ultrasound technology, or HIFU, has been the core business for China Medical Technologies CMED. Sales of the tumor-fighting systems provided 60% of...