The registered trademark name for disulfiram is Antabuse—it is the most commonly used medication for the treatment of ALCOHOLISM and the only one of two medications (the other being naltrexone) approved for this use in the United States, as of...

Antabuse, also known by its scientific name disulfiram, is a medication that was approved in 1951 by the U.S. Food and Drug Administration (USDA) for the treatment of alcoholism. It deters the drinker's desire for alcohol by causing extremely...

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Disulfiram is a drug used to support the treatment of chronic alcoholism by producing an acute sensitivity to alcohol. Trade names for disulfiram in different countries are Antabuse and Antabus manufactured by Odyssey Pharmaceuticals. Disulfiram is...

INTRODUCTION Disulfiram is an important drug in the supportive therapy of alcohol addiction.[1 ] Several cutaneous reactions to this drug have been described.[2 ],[3 ] Disulfiram reactions in nickel sensitive individuals are known.[4 ],[5 ],[6 ] We came across a patient whose nickel...

Sir, The trypanothione biosynthetic pathway, common to the trypanosomatid family of protozoa (which includes Leishmania and Trypanosoma), is absent in the host systems. This pathway constitutes an important target for chemotherapy against leishmaniasis. The trypanothione pathway combines two metabolic pathways - the polyamine...