David Mitchell may refer to:
- David Mitchell (bishop), d. 1663
- David Mitchell (Royal Navy officer) (c1642-1710), British admiral of the late seventeenth century.
- David Brydie Mitchell (1760-1837), American politician (Georgia).
- David Mitchell (builder) (born c.1830), builder of Scots' Church, Melbourne and father of Dame Nellie Melba.
- David Scott Mitchell (1836-1907), founder of the Mitchell library, Sydney,
- David Mitchell (politician) (born 1928), former Conservative Member of Parliament (UK).
- David Mitchell (footballer) (born 1965), Australia.
- David Mitchell (footballer born 1866), Scottish footballer who played for Rangers F.C.
- David Mitchell (author) (born 1969), author of Ghostwritten, number9dream, Cloud Atlas, and Black Swan Green.
- David Mitchell (actor) (born 1974), English actor and comedian, star of Peep Show and That Mitchell and Webb Look.
- David Mitchell (Irish actor) (born 1973), Fair City star.
- David Mitchell (figure skater), American ice dancer.
- Dave Mitchell, American broadcast personality.
- David Mitchell was a Staff Sergeant present at the My Lai Massacre

