In this literary novel presented as an interview transcript, Taylor Jenkins Reid narrates the story of a fictitious 1970s rock band named Daisy Jones & The Six. The story focuses primarily on the band's two talented but mercurial lead singers, Daisy Jones and Billy Dunne. Both Billy and Daisy struggled with addictions to drugs and alcohol, but also continually wrestled with their attraction to one another, since Billy was committed to his wife Camila. The novel also tracks the romantic relationship between keyboardist Karen Sirko and lead guitarist Graham Dunne, and the ongoing feud between Billy and the band's rhythm guitarist Eddie Loving. Over the course of its narrative, Daisy Jones & The Six explores themes related to integrity, artistic passion, addiction, and family bonds.