Replisome refers to a complex of proteins that are engaged in the elongation of the newly synthesized strand of deoxyribonucleic acid. The replisome assembles at the replication fork, the region where the new DNA stand is being made. The replisome...

DNA polymerase III holoenzyme is the primary enzyme complex involved in prokaryotic DNA replication. It was discovered by Thomas Kornberg (son of Arthur Kornberg) and Malcolm Gefter in 1970. The complex has high processivity (i.e. the number of...

The primary role of DNA polymerases is to accurately and efficiently replicate the genome to ensure the maintenance of the genetic information and its faithful transmission through generations. This is not a simple task considering the size of the genome and its constant exposure...

ABSTRACT Most replicases are multi-subunit complexes. DNA polymerase epsilon from Saccharomyces cerevisiae is composed of four subunits: Pol2p, Dpb2p, Dpb3p, and Dpb4p. Pol2p and Dpb2p are essential. To investigate a possible role for the Dpb2p subunit in maintaining the fidelity of DNA replication,...