Paul Nurse is a researcher in cell biology and biochemistry, and is best known as the discoverer of CDK (cyclin dependent kinase), one of the key regulators of the cell cycle. Nurse studied biological science at the University of Birmingham, England,...

Cyclin-dependent kinase inhibitors, such as the mammalian p27^sup KiP1^ protein, regulate correct cell cycle progression and the integration of developmental signals with the core cell cycle machinery. These inhibitors have been described in plants, but their function remains unresolved. We have isolated seven genes...

Two maize (Zea mays) cyclin-dependent kinase (CDK) inhibitors, Zeama;KRP;1 and Zeama;KRP;2, were characterized and shown to be expressed in developing endosperm. Similar to the CDK inhibitors in Arabidopsis (Ambidopsis thaliana) and tobacco (Nicotiana tabacum), the maize proteins contain a carboxy-terminal region related to the...